Located on the Rhine River near the borders of France and Germany, Basel contains the country's highest concentration of museums. The culture-centric city, site of the world's most influential art market each June, is also home to the lovely Munster Cathedral, made of red sandstone with a multi-colored tile roof. Green spaces abound, including the popular zoological gardens in the city center. Switzerland's largest site of Roman ruins, Augusta Raurica, are an easy day trip to the east.

Grindelwald is postcard-perfect, a charming example of a Swiss ski resort. There are slopes for all experience levels, plus plenty of snowy activities for those who don’t ski, such as sledding, hiking or snowshoeing. Not feeling particularly active? Just cozy up by crackling fire and enjoy the merry atmosphere. After a long day, nothing’s better than lingering over a pot of Swiss fondue and a glass of crisp wine as you plan the next day’s adventures.

The pint-sized town of Rust, sandwiched between the Black Forest and the Rhine, belies its small size and quaint country-town facade by harboring Europa-Park, one of Germany’s top family attractions, as well as one of Europe’s largest theme parks.

Glitzy Lech is one of Austria's most moneyed resort towns. Pricy, posh palaces abound, but this ostentatious, old-school winter wonderland has accommodation and a place on the pistes for all budgets. Popular since the 1920 and 1930s, this former farming town has managed to retain its original character and charm. Its somewhat isolated location forces an often tricky drive in inclement weather but also is part of what appeals to celebrity admirers. Nearest airports are Zurich and Innsbruck.

The “Red City” of Marrakesh is a magical place, brimming with markets, gardens, palaces, and mosques. Exploring the intimate courtyards and snaking alleyways of the historic Medina can easily eat up a day. Find inner peace at the serene Jardin Majorelle or take in the beauty of one of the city’s historic mosques (taking note that, unless you are Muslim, you are not allowed to enter).

The mighty Nile has been providing Egypt with water for millennia. Deserving of its reputation as the world's largest open-air museum, the Nile River Valley contains thousands of monuments at sites such as Luxor and Aswan. Don't miss the city of temples ar Karnak, the dozens of tombs in the Valley of the Kings, the massive rock temples of Abu Simbel or vast and powerful Luxor Temple. Visitors can float by these astounding sites on a felucca boat or cruise ship or catch a train from Cairo.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

The Zanzibar Archipelago, located in the Indian Ocean 15 miles off the coast of Tanzania, is a breathtaking spot to escape from the world. You’ll enjoy clear, turquoise-blue water; shallow sandbars perfect for wading; and many small, nearly deserted islands virtually unvisited by tourists. Explore the World Heritage Site of Stone Town, Zanzibar City’s old quarter. Or just go beach to beach between tiny fishing villages—each one's better than the next.

Pennsylvania Dutch country is a fascinating destination to explore. Visitors will get a glimpse of farm life as it was in the early 1800s. Visit markets and farm stores for homemade shoofly pie and fresh produce, or shop for a handmade quilt. President James Buchanan's elegant home, Wheatland, is no less historic but contrasts sharply to the simpler Pennsylvania Dutch heritage sites in Lancaster. Consider a side trip to nearby Hershey, home of Hershey Park and the Hershey chocolate factory.

East meets West in this sun-soaked state, where Indian culture intertwines with Portuguese influences left over from a 500-year occupation. The beaches have long served as a magnet for serene hedonists. To the north, the tourist-centric scene is prevalent, with an international flair that is now skewing more hip than hippie. Travel south for stretches of unspoiled sand and an escape from large resorts. Temples, mosques and wildlife sanctuaries provide diversions from the beach.