Gatlinburg, at the heart of Great Smoky Mountains National Park, is an ideal base for a family looking to explore the park's numerous offerings. After you've gone hiking, fishing, rafting or horseback riding, ride an elevator 342 feet to the top of the Gatlinburg Space Needle for stunning views of the Smokies. There's also an amusement centre next door with nifty rides and games.

If you’re into eating locally and supporting sustainable agriculture, go to Ashville—and eat, eat, eat. This town of less than 100,000 people has 17 farmers’ markets, and the local restaurant scene is all about taking advantage of the seasonal produce sold there. And don’t miss the area’s microbreweries.

Nestled in the fertile Susquehanna Valley, Harrisburg has played a pivotal role in the shaping of American history, both as a major link in rail and water transportation and as the setting of major Civil War battles. Having bounced back from economic distress in the 1980s, the city is now a vibrant hub of family activities, from cruises along the Susquehanna to arcades and athletics on City Island. The annual Pennsylvania Farm Show is the largest indoor agriculture exposition in the U.S.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Billing itself as one of Denmark's friendliest towns, Kolding certainly appears welcoming—its streets lined with cherry red Danish flags that seem to be constantly waving hello. A medieval castle towers over vibrant parks that bloom with flowers and medicinal spices. On balmy days families will be grateful for SlotssøBadet, an extraordinary waterpark that's a blast for all ages.