Nestled at the foot of the Black Forest in South Germany, Baden-Baden is a chic destination for those who fancy a dip in its famous salt- and radon-rich thermal hot springs. The town has been a popular destination for so long that it's starting to show its age, but not to worry. It's still very classy, picturesque and well-maintained. (The Dame Julie Andrews of German spa towns, if you will.) Sporty types will find an abundance of opportunities to enjoy golf, tennis, horseback riding and skiing nearby in winter.

Home to the oldest university in Germany, Heidelberg was hit hard during 17th-century wars and rebuilt in the 18th century with baroque buildings. For a pleasant walk, stroll through the historic city centre's Gothic streets. Be sure to take in Heidelberg Castle, the symbolic heart of the city; Alte Brucke, a beautiful 18th-century bridge; and the Student Jail. Built as long ago as the 16th century, it was used to keep mischievous students off the streets for three days to a month at a time. And they say Penn State is the number-one party school!

Fairytale villages, thermal baths, casinos and pine and birch-blanketed mountains beckon travelers to southwestern Germany's Black Forest. Scenic drives and train trips showcase the best of the area. Skiing, hiking, mountain climbing, boating and ice-skating are popular activities. Baden-Baden's Roman-Irish baths, 19th-century performance hall, casino and fresco-adorned Pump Room are much visited. Gothic masterpiece Freiburg Cathedral and its famous Boys' Choir also draw visitors.

Walk atop Rothenburg’s city walls or climb to the top of the town hall for great views. The Night Watchman tour is an unforgettable way to learn the city’s history. And our travelers also recommend the Medieval Crime Museum (Mittelalterliches Kriminalmuseum)—it’s gruesome but fascinating.

Named by American soldiers during the post-World War II occupation years, the Romantic Road is a 200-mile-plus section of one of Germany's most picturesque highways, stretching from Würzburg in Bavaria's north to Füssen near the Austrian border. Along the route are many favorite tourist towns and attractions, including Rothenburg ob der Tauber, Dinkelsbühl, Augsburg, and Neuschwanstein and Hohenschwangau Castles. Bike tours along the route are quite popular, and bus tours are also available.

You view great wine as the essence of a good holiday. Your travel companion, however, is a beer aficionado. Will it be Paris or Munich? Stop arguing and go to Strasbourg, where you can have the best of French and German cuisine, including the booze. The entire central island is a World Heritage Site. Don’t miss the 12th-century cathedral or the storybook "la Petite France" neighbourhood.

A gorgeous spot that’s a convenient day trip from Milan, Lake Como recently earned fame as home to Hollywood star George Clooney. But celeb-spotting aside, it’s known for jaw-dropping natural beauty, elegant old villas—and the scenic towns surrounding the lake. Check out Varenna, Bellagio, and Menaggio, which offer great views, historic churches, and water-based activities such as ferries and passenger-only boats.

History lovers should know that Milan is not all about trendy shops and designer clothes. Among the city's many historical attractions are La Scala Opera, the Milan Cathedral, the National Museum of Science and Technology and Santa Maria della Grazie, the church that preserves da Vinci's "Last Supper".

This picturesque Umbrian city has a history that spans many eras. The city wall and arch are Etruscan; the sixth-century Sant'Angelo church was built atop a Roman temple; the town's cathedral is both Gothic and Renaissance. If you have a sweet tooth, visit the famous Perugina chocolate factory; if you have a full set of sweet teeth, visit during the Eurochocolate festival, held in October, when the entire town reportedly smells of chocolate.

The town that gave the country (and port wine) its very name, Porto is Portugal’s second-largest metropolis after Lisbon. Sometimes called Oporto, it's an age-old city that has one foot firmly in the industrial present. The old town, centered at Ribeira, was built on the hills overlooking the Douro River, and today is a UNESCO World Heritage Site. The 14th-century São Francisco church is a main attraction, as are the local port wine cellars, mostly located across the river at Vila Nova de Gaia.

Nicosia, the capital of the island of Cyprus, has incorporated elements of the many empires and kingdoms that have claimed it over centuries stretching back to the Bronze Age. Narrow winding streets lead visitors from the Cyprus Museum, with its collection of Neolithic and Roman artifacts, to the thick city wall. Built in the 1600s by the Venetians, the wall now divides the ancient part of the city from the modern. Step through the stone gates and enter a place where the past is still alive.