Home to nearly nine million and powering an economy that exceeds both Hong Kong's and Thailand's, Osaka packs quite a punch. The confident, stylish city is a shopping hub, with fabulous restaurants and nightlife. It's an ideal base for exploring the Kansai region: Kyoto's World Heritage Sites, Nara's temple and Koya-san's eerie graves are within 90 minutes by train. Top city attractions include the aquarium, Osaka Castle, Universal Studios Japan and the futuristic Floating Garden Observatory.

Shanghai is the cool, confident face of modern China, and its energy is infectious. Go to the Bund to watch ships on the river and marvel at the huge variety of architectural styles on display, or watch the crowds go by in People’s Square. Shoppers should make a beeline for the Fabric Market, where you can have a suit or dress tailor-made for you at bargain prices. At night, explore all manner of fashionable restaurants, bars and nightclubs or just stroll through the city enjoying the spectacular neon lights.

Tradition collides with pop culture in Tokyo, where you can reverently wander ancient temples before rocking out at a karaoke bar. Wake up before the sun to catch the lively fish auction at the Toyosu Market, then refresh with a walk beneath the cherry blossom trees that line the Sumida River. Spend some time in the beautiful East Gardens of the Imperial Palace, then brush up on your Japanese history at the Edo-Tokyo Museum. Don’t forget to eat as much sushi, udon noodles, and wagashi (Japanese sweets) as your belly can handle.

You can eat very well—and very cheaply—in Taipei. The restaurants may not look posh, but the quality of the food is superlative. And there’s a huge variety of restaurants—in addition to local Taiwanese specialties, you’ll find regional cuisines from all over China, as well as great Indian, Japanese and even Italian options. Just make sure to leave some room for snacks—street-vendor food here is addictive.

Hong Kong's a great city for an adventurous eater. Stop at a street vendor for fish balls on a stick or stinky tofu. Bakeries offer wife cake, pineapple buns and egg tarts. Or opt for as much dim sum as you can eat. If you're tired of local and regional Chinese specialties, check out upscale offerings from some of the world's top chefs, like Joel Robouchon and Alain Ducasse.

Bangkok is full of exquisitely decorated Buddhist temples—as you go from one to the next you’ll be continually blown away by the craftsmanship and elabourate details. But if you’d rather seek enlightenment in a gourmet meal, or dance the night away, you’ll also enjoy Bangkok—the restaurant and nightclub scenes here are among the best in the world.

Singapore is known as a bustling metropolis that also happens to be one of the cleanest and safest cities of its size in the world. (Just make sure you heed the local laws—something like spitting in the street might merely be considered rude in your hometown, but here, it carries a severe penalty.) You'll find historic sites like the Thian Hock Keng temple, superlative shopping (including gargantuan malls) and numerous beaches.

Bali is a living postcard, an Indonesian paradise that feels like a fantasy. Soak up the sun on a stretch of fine white sand, or commune with the tropical creatures as you dive along coral ridges or the colorful wreck of a WWII war ship. On shore, the lush jungle shelters stone temples and mischievous monkeys. The “artistic capital” of Ubud is the perfect place to see a cultural dance performance, take a batik or silver-smithing workshop, or invigorate your mind and body in a yoga class.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Australia’s third-largest city, Brisbane is the hub of Queensland culture, offering a peek at the past and a glimpse into the future. Visit the historic Windmill and Old Commissariat Store, built by convicts in 1828, or fast-forward to the present (and beyond) with a trip to the new Gallery of Modern Art. Mingle with locals atop Mount Coot-tha, cruise the Brisbane River to South Bank’s sandy beach on the City Cat and make sure to fill the cuteness quota at Lone Pine Koala Sanctuary, home to koalas and kangaroos.