Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Bisbee has declined in size and vigor from its glory days as a thriving silver and copper mining town, but the decrease in population has not robbed the vitality from this historic center. A haven to artists, retirees and history buffs, Bisbee astounds visitors with vibrantly colored rock faces and picturesque houses hugging the edges of cliffs. Its history can be discovered in its numerous museums, historic staircases and a mine tour that leads deep into one of the remaining caverns.

Everything about Santa Monica sizzles, from hundreds of funky shops and restaurants to more than three miles of white sandy beach, to the multitude of celebrities zipping into the local airport and out on Montana Avenue. The subject of popular songs, movies and television shows ("Baywatch" was one of many filmed here), the city has a vibe like no other. Hollywood haute couture meets surfer chic meets hippie casual, and somehow it all works. A word of advice: ditch the car and walk everywhere. Santa Monica is small and prides itself on being pedestrian- and environmentally friendly. You won't need wheels at the auto-free Third Street Promenade, a stroller's paradise known for its multitude of cinemas, restaurants and street performers. Or at the famous and historic Santa Monica Pier, home to tempting smells from fast-food stalls and the solar-powered, nine-storey high Ferris wheel that has long been a symbol of the city. If your feet start to fail, hop on the electrically powered Tide Shuttle, a bus service that runs along the beach offering great views plus a ride to the artsy Bergamot Station and the Santa Monica Museum of Art, or your next spirited Santa Monica destination.

Steeped in history, Vancouver is the oldest city in Washington. Once the largest western outpost of the British Hudson's Bay Company, where supplies and food were bartered in the 1800s, it was closed in 1860 as Americans took over commerce. The outpost was later recreated as the Fort Vancouver National Historic Site. For more history, check out the Pearson Air Field, the oldest operating airfield in the West, where vintage aircraft are displayed at the Pearson Air Museum. If adventure is your bag, Vancouver is the perfect base for day trips to the Columbia River Gorge, the breathtakingly beautiful 70-mile river stretch that cuts through the Cascade Mountains, or Mount St. Helens, the site of the famous volcano, both of which offer a slew of outdoor activities. For calmer pastimes, cruise the picturesque river in the Columbia Gorge riverboat, or visit Beacon Rock, the world's second largest monolith, where a walking trail leads to spectacular panoramic views.

With its gleaming skyscrapers set amid glittering lakes, Minneapolis makes for an attractive and fun getaway. A truly year-round destination, the city offers activities for every season. In winter, one can explore the downtown area through more than seven miles of glass-enclosed skyways. In addition to keeping you warm, they create a lively thoroughfare filled with speciality shops, restaurants and services. Whether you want to escape the winter cold or the summer warmth, the Mall of America offers shopping, dining and entertainment options for any time of the year and every member of the family. Art lovers have plenty to see at the Minneapolis Art Institute, Walker Art Centre and the Frederick R. Weisman Art Museum, which all house world-renowned collections. The theatre scene is thriving. With more than thirty theatres, Minneapolis has more seats per capita than any U.S. city except New York. See a Broadway show and enjoy dinner and live jazz at a fabulous restaurant. With kids in tow, check out the Science Museum of Minnesota, where visitors can produce their own video, or come face to face with a shark at the UnderWater Adventures Aquarium. In summer, the action moves outside. Known as "The City of Lakes," Minneapolis has 22 lakes located within city limits and many more in the surrounding area. In town, hordes of locals and tourists in-line skate or stroll around Lake Calhoun, stopping for ice cream along the way. Just outside of town, Fort Snelling State Park offers outdoor recreational activities from hiking to biking and golf to boating. No matter when you visit, Minneapolis offers lots for everyone to enjoy.

Any city that can be the butt of a Simpson's joke ("That's it! We're all going back to Winnipeg!") and simultaneously one of the most vibrant cultural centres in Canada is tops in our book. The city's history of isolation and self-sufficiency means that Winnipeggers are unpretentious and sincere (and fun-loving enough to name Homer an honourary citizen). Though the winters are long and cold, there are plenty of indoor activities to both keep you warm and stimulate your imagination.

Although not a crowded Caribbean tourist spot, Georgetown is a unique city that serves as a perfect jumping point for ecotours into the South American interior. Its Victorian and Dutch Colonial architecture is detailed with louvered window shutters and brick and stone work. Built below the high tide level, the city is protected by a large seawall and drained by a grid of canals. Sundry goods can be found at the distinctive Stabroek Market, while the landmark Light House offers panoramic views.