Perched on the banks of the dreamy Lácar Lake, San Martin de los Andes is a Patagonian paradise. Birdwatchers flock and flutter to the annual South American Bird Fair, while thrill seekers love to kayak, ski, or mountain bike along the gorgeous landscape. Arts and crafts shops and artisan food producers will delight visitors that love a sensory sampling of local cultures.

Building on its must-visit location, the once-tiny El Calafate has grown quickly to cater to and profit from the visitors to nearby Los Glaciares National Park. Many visit to see such natural wonders as Perito Moreno Glacier, a massive glacier that’s actually composed of many other pieces of shifting ice. Yet travellers will find that El Calafate is much more than merely a gateway to the Patagonian wild—it’s a fun town offering all sorts of outdoor adventures.

Perched at the Triple Frontier, where Brazil, Paraguay and Argentina meet, Puerto Iguazu is linked to Brazil by the Tancredo Neves bridge. It is home to the Museum of Images of the Jungle, the Mborore Museum, a bird rehabilitation center and the famed Iguazu National Park. The National Park is home to 275 waterfalls, including the world-renowned Iguazu Falls, which plunges 270 feet. A subtropical climate means it's warm in winter and hot in summer, with temperatures soaring up to 104°F.

Sure, you can leave the sunny sands in favor of a crocodile watch or horseback ride, but when the main strand is called Seven Mile Beach, it's clear what draws most visitors to Negril. Depending on how much sun you want, you're welcome to go topless or even sunbathe in the buff in some places.

You don't have to choose between visiting a cultural capital or a sunny Caribbean beach destination—San Juan is both. This city's architecture ranges from Spanish colonial to 20th-century Art Deco, while the new Museo de Arte de Puerto Rico presents Latin American and Caribbean artwork in state-of-the-art galleries.

Once a sleepy fishing village, Placencia has emerged as an increasingly popular eco-destination on the Caribbean. For those who enjoy outdoor adventure, the Stann Creek region offers a host of activities: hiking through mountainous rain forests, kayaking, deep sea fishing, diving and exploring Mayan ruins. The peninsula boasts 16 miles of tranquil beaches, with a lagoon to the west and the Caribbean to the east and lots of peace and quiet in the middle. Tour guides and dive centers offer a variety of excursions, with boat rides to the outer cayes an ongoing favorite. Also popular are guided land tours to Mayan Ruins or trekking the jungle trails of Cockscomb Basin Wildlife Sanctuary, where the first Jaguar Reserve in the world was established.

Crystal clear waters beckon from the south part of this tranquil Caribbean islet, a hundred miles south of Havana and known for its17 miles of stunning white sand beaches, mangrove forests and scuba diving to the black coral reef. The largest of the 300 keys and islets in Los Canarreos Archipelago, waters in the north are much cloudier. Cayo Largo also offers excellent deep sea fishing. Rent a jeep to explore the islet’s few roads and paths or trot across coral sand beaches on horseback.

New Orleans is full of life—but with a laid-back energy that sets it apart from other cities. You’ll wanna soak it all in: impromptu jazz performances up and down Frenchmen Street, the ding of the St. Charles Streetcar, moss-draped trees in the famous Garden District…even its gothic, above-ground cemeteries. (The city’s said to be one of the most haunted in America.) For some, NOLA will always be all about Bourbon Street, but for travellers looking to take it slow, the city’s distinct blend of cultures—including Creole and Cajun—means there’s tons to see, explore, and yes, eat.