Who cares about a little fog (okay, a lot of fog) when there’s so much to do in San Francisco? By day, explore Fisherman’s Wharf and the Aquarium of the Bay, ride a cable car, and stroll around the Presidio; by night, have a fabulous dinner (at a Michelin-starred restaurant or a tiny place in Chinatown), then hit some of the best clubs on the West Coast.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Seattle's petite downtown area and many attractions make it possible to pack a week’s experience into a weekend. Grab a latte and start at the world-famous Pike Place Market. Watch the fish fly and then head to the Space Needle for a dramatic view of the city and its surrounding waters. Return to earth and jump aboard a moonlit dinner cruise to Blake Island or canoe through the arbouretum.

Have you ever wanted to experience elevated city life? Then step on up to The Mile High City! Denver gives you the best of both worlds with mountain adventures and city excitement. Access to the majestic Rocky Mountains is a breeze and only an hour drive away, making Denver your perfect basecamp. During your stay, check out the award-winning dining scene with 26 Michelin-rated restaurants that will have you dining like a star. But, the fun doesn’t stop there! With a thriving and diverse arts and culture scene, live music at bucket-list concert venues, and championship level professional sports, you can truly do it all in Denver. Elevate your next getaway, and find Mile High City recommendations below!

Houston hums with an energy and independent spirit all its own. A leading cultural and culinary destination in the South, the city is home to over 11,000 restaurants featuring cuisine from more than 70 countries. The thriving arts scene includes resident opera, ballet, symphony and theatre companies. The Museum District houses 19 museums, all within walking distance. Be sure to visit Space Centre Houston, where you can visit NASA’s Historic Mission Control at the Johnson Space Centre.

New Orleans is full of life—but with a laid-back energy that sets it apart from other cities. You’ll wanna soak it all in: impromptu jazz performances up and down Frenchmen Street, the ding of the St. Charles Streetcar, moss-draped trees in the famous Garden District…even its gothic, above-ground cemeteries. (The city’s said to be one of the most haunted in America.) For some, NOLA will always be all about Bourbon Street, but for travellers looking to take it slow, the city’s distinct blend of cultures—including Creole and Cajun—means there’s tons to see, explore, and yes, eat.

It’s not just for spring-breakers. Cancun, with its golden beaches and perfect climate, is the premiere coastal destination in Mexico. And while there is certainly a 365-day party available for college students, resorts cater well to families and to those seeking solitude. This Yucatan paradise is also the gateway to the ruins of Tulum and Chichén Itzá.

Although much of Jacksonville is urban, this sprawling northeastern Florida city also has nature and wildlife reserves, historic residential neighbourhoods and lots of golf courses. Attractions in Jax, as the locals call it, range from art, science and history museums to a brewery tour, from the Jacksonville Landing entertainment complex, along the St John's River, to Bronson Motor Speedway. The city's beaches offer soft sand and warm water - perfect for swimming, surfing and kayaking.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.