Halfway between San Francisco and L.A., San Luis Obispo can be a relaxing getaway or a buzz of activity. For serenity, pack a lunch and head to one of dozens of wineries or take a drive to the beach for a leisurely swim. For a dose of history, visit the heart of the city at the beautiful Mission San Luis Obispo de Tolosa. Kids will love the Children’s Museum or Skate Park. Be sure to stroll along the creek downtown, where there are breweries, wine bars, restaurants and shopping for all tastes.

Kissimmee provides the perfect base camp for a date with Mickey. Only a few minutes' drive from the Walt Disney World theme parks, the Florida town is packed with family-friendly activities like mini golf, dinner theatre and ice skating. Get close to nature on an air boat ride through the swamps or pick oranges at a local grove. For a more educational diversion, stroll through the historic downtown or visit the Osceola County Historical Society and Pioneer Museum for a peek into turn-of-the century life.