Halfway between San Francisco and L.A., San Luis Obispo can be a relaxing getaway or a buzz of activity. For serenity, pack a lunch and head to one of dozens of wineries or take a drive to the beach for a leisurely swim. For a dose of history, visit the heart of the city at the beautiful Mission San Luis Obispo de Tolosa. Kids will love the Children’s Museum or Skate Park. Be sure to stroll along the creek downtown, where there are breweries, wine bars, restaurants and shopping for all tastes.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Although Tucson's fantastic weather, national parks and forests and desert provide the perfect environment for lots of outdoor recreational activities, this city of half a million people also has its share of history and culture. With a history that goes back much further than many of its southwestern neighbours, Tucson boasts turn-of-the-century architecture, historic neighbourhoods, museums and the Mission San Xavier del Bac, a still-functioning 18th-century mission considered one of the most beautiful in the USA. Mexican and Native American influences are pervasive, and the city has a distinctly Western flavour. There's also a college-town atmosphere, thanks to the University of Arizona, which has its own share of museums and a science centre. Whether golfing at a world-class golf resort, horse riding, hiking in the wilderness, discovering desert flora and fauna at the Arizona-Sonora Desert Museum, or exploring pre-Columbian and other art at the Tucson Art Museum, you'll have a mind-boggling array of things to do.

The next time you're driving to Toronto or Niagara Falls, stop in Hamilton, where tourist traffic isn't quite so rampant. The Niagara Escarpment provides spectacular scenery, with beautiful trails and waterfalls. Visit nearby farms, orchards and vineyards, or plan your trip to coincide with Hamilton's lively fall fairs.

A short Metro ride from Washington DC, Alexandria, Virginia is the perfect escape from the fast-paced capital. First settled in 1695, the city retains its colonial spirit, with cobblestone streets and historic buildings in the Old Town, Gadsby's Tavern, a restaurant serving food since 1770, and centers of learning like the Black History Museum. For a more contemporary side of Alexandria, wander the streets of the stylish Del Ray neighborhood, where local artists operate boutiques and studios.