Families with kids of all ages will love this mountain village, located just two hours from Panama City. Whether you’re up for active sports such as hiking, biking, horseback riding and ziplining through the rainforest—or sightseeing adventures such as the El Nispero Zoo and Serpentario (a snake habitat), you’ll find it here. El Valle de Antón is home to the world’s second-largest extinct volcano—but you’ll still find more modern pleasures here, such as its well-known Sunday Market and elegant spas such as Casa de Lourdes.

Nestled in the towering San Juans, Telluride offers visitors abundant trout fishing and hiking opportunities in summer, plus downhill and cross-country skiing in winter. One of the world’s most beautiful ski resorts, this former gold-rush town has been popular with skiers since the ’70s. Walk, catch free shuttles or soar to 9500 feet on the Mountain Village gondola. Appreciate the area’s history and beauty at Telluride Historical Museum and Bridal Veil Falls, Colorado’s longest free-falling falls.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Located along the Willamette River and its namesake lake, the city of Lake Oswego has a beautiful downtown area featuring riverfront parks, boutique shopping and speciality dining including a European-style farmers market open from May – October. Lake Oswego also offers visitors an active arts scene: Visitors can take a self-guided tour of the outdoor “Gallery Without Walls,” or attend the annual Festival of the Arts in June.