We won't lie: Niagara Falls is uber-touristy. There are wax museums and a Ripley's Believe It or Not Museum, and if it's a fast-food chain, you can probably find it here. But even the most jaded hipster shouldn't pass up a chance to visit this town, because the Falls themselves are spectacular.

A popular spot for getting wowed or soaked amid natural splendor, Niagara Falls attracts curious spectators and adventurous honeymooners from around the world. The splendid main attraction - more than six million feet of water cascading over a rocky crest - sits partially in the United States and partially in Canada. The U.S. side has recently been busy promoting other activities to lure visitors. Venues like the Aquarium of Niagara offer parents fun and engaging alternatives for kids, after or in between visits to the Falls. Outdoor recreation such as hiking, biking, fishing and camping can be found at the Niagara Falls State Park. The storied history of attempts to conquer the majestic Falls is captured at the Daredevil Museum; the Schoellkopf Museum concentrates on the history and geology. There's more to the Falls than, well, the Falls, including a wide array of dining and lodging options, from budget to upscale. This awe-inspiring region makes for an exhilarating and multi-faceted getaway

Buffalo is being reborn as a mecca for art, architecture, history, culture, dining and entertainment. Experience Frank Lloyd Wright’s stunning Darwin Martin House Complex and world-class modern art at the Albright-Knox Art Gallery. Relive part of the city’s incredible history at the Theodore Roosevelt Inaugural National Historic Site. Explore the emerging Canalside waterfront district, hip Elmwood Village, more than 400 independently owned restaurants (serving our famous chicken wings and more) and nearby Niagara Falls.

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

Home to two of America's most prestigious universities, Cambridge exudes a certain intellectual quirkiness. A mix of historical haunts, student hang-outs, alternative art and culture venues, vintage clothing shops, bookstores and ethnic restaurants, the city is, well, really cool. Although it is located just across the Charles River from Boston, Cambridge has a distinct vibe that is noticeable immediately. Start at Harvard Square, a hub of activity and mishmash of trendy stores, outdoor cafes and colorful local characters. Pick up a walking tour map at the visitors information booth in the centre of the Square. The route will take you past many important landmarks including the Mount Auburn Cemetery, Tory Row and the Longfellow National Historic Site. Harvard University offers student-led tours through the illustrious buildings and monuments of its sprawling campus. Art and architecture buffs should meander around the M.I.T campus, which includes outdoor sculptures by masters such as Picasso and 20th-century buildings designed by modern greats like Eero Saarinen and I. M. Pei. Along the way, browse through bookstores, stop to watch street performers and grab a coffee at an outdoor café to take in all this captivating city has to offer.

Quebec City may be the only fortified city north of Mexico, but it welcomes visitors with open arms. Explore the Citadel, where you might catch Canadian troops staging a military ceremony. As for food, you could splurge on afternoon tea at the Chateau Frontenac, or do as the locals do and snack on poutine—french fries with gravy and cheese curds.

Greenville, South Carolina, is a welcoming place to shop, dine, see historic homes and watch minor-league sports. The city is also home to significant art collections and a vibrant performing-arts scene. Families can enjoy child-friendly activities such as searching for nine bronze mice scattered around the city, visiting the Greenville Zoo, relaxing in the many outdoor spaces and enjoying numerous annual festivals. State parks and Revolutionary and Civil War sites are a short drive away.

With live music to be heard all across town, 24/7, 365 days a year, Music City lives up to its name. From honky-tonk bands jamming at Tootsie’s Orchid Lounge to songwriters in the round at the Bluebird Cafe and country music legends rocking the Grand Ole Opry, you never know who you might see. The creative spirit from Nashville's music landscape flows into the area's myriad art galleries, up-and-coming fashion scene, historic landmarks and chef-driven restaurants.

With its gondolas, canals, amazing restaurants, and unforgettable romantic ambiance, Venice is definitely a city for one's bucket list. Waterfront palazzos, palaces, and churches make drifting down the Grand Canal feel like cruising through a painting. To really experience Venice you must go to the opera or to a classical music performance, nibble fresh pasta and pastries, and linger in the exhibit halls of an art gallery. Label lovers will drool over the high-end shopping in Piazza San Marco.

Wroclaw is Poland’s fourth-largest city and the capital of the Viovodship of Lower Silesia. Originally (in medieval times) built across several islands, the city still has many lovely bridges and beautiful architecture. The Rynek (central square), lined by colorful buildings, is one of the city’s most popular destinations.

Three miles of twisty mountain roads up from Amalfi, the gorgeous resort of Ravello has been attracting celebrities for centuries, including Richard Wagner, Greta Garbo, Gore Vidal and D.H. Lawrence, who wrote Lady Chatterley’s Lover here. Ravello’s Duomo (Cathedral) and Villa Cimbrone (both 11th century) and Villa Rufolo (13th century) are all magnificent sights. The annual summer Ravello Festival began as a salute to Wagner’s music, but now showcases a wide range of music and arts.

A patchwork of vineyards and olive groves, dotted with whitewashed hill towns and sun-bronzed beaches—Italy’s southern heel has no shortage of photogenic landscapes. There are a few surprises, too, including the baroque city of Lecce and the Itria Valley, with its UNESCO-listed trulli houses.

California’s desert regions fascinate visitors with the unexpected. Vast expanses, wide salt flats and ghost towns are on full display in In the quintessential desert at Death Valley National Park. Visit Joshua Tree National Park to see both the Mojave and Colorado desert landscapes, where wildflower blooms offer a spectacular sight every spring. Don’t miss the sculpture gardens and hiking trails of Anza-Borrego Desert State Park.