Once a vital part of a mighty sea power, Positano is today a sophisticated resort on the central Amalfi Coast. Moorish-style architecture rises up steep slopes that gaze out on the Sirenuse Islands. Smart boutiques, selling fashions for visitors to display on Grand Beach, abound in the village. And it’s a great base for exploring the area—you can easily travel by boat to Capri, Ischia and the Grotta dello Smeraldo cave.

Copenhagen is one of Europe’s oldest and most popular cities. It’s also one of the cleanest and most metropolitan. The dynamic Danish capital features progressive modern architecture, the must-visit Tivoli Gardens amusement park, stunning palaces, and all the activities and amenities you would expect in a world-class destination. Explore the canals and pretty narrow streets, appreciate beautiful old homes, and find great shopping and people watching on The Ströget.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

Fort Wayne serves up the perfect mix of urban convenience and natural beauty, boasting a world class cultural scene in a landscape enhanced by plenty of green space. Shopaholics can find the latest trends at open air Jefferson Pointe. The kids will love the Fort Wayne Children's Zoo, while the adults can take in a performance at the Embassy Theater. Joggers, hikers and cyclists can keep active on the Rivergreenway that links the city's parks, where they may come across Johnny Appleseed's Grave.