Although Tucson's fantastic weather, national parks and forests and desert provide the perfect environment for lots of outdoor recreational activities, this city of half a million people also has its share of history and culture. With a history that goes back much further than many of its southwestern neighbours, Tucson boasts turn-of-the-century architecture, historic neighbourhoods, museums and the Mission San Xavier del Bac, a still-functioning 18th-century mission considered one of the most beautiful in the USA. Mexican and Native American influences are pervasive, and the city has a distinctly Western flavour. There's also a college-town atmosphere, thanks to the University of Arizona, which has its own share of museums and a science centre. Whether golfing at a world-class golf resort, horse riding, hiking in the wilderness, discovering desert flora and fauna at the Arizona-Sonora Desert Museum, or exploring pre-Columbian and other art at the Tucson Art Museum, you'll have a mind-boggling array of things to do.

Hit the casinos, watch big-name entertainment and stay at a themed hotel. Las Vegas? No, but this small gambling town on the banks of the Colorado River offers a taste of Vegas minus the glitz, traffic and high costs. Plus, there's plenty to do here besides gambling. Not only does Laughlin have the Colorado River for boating, swimming, fishing, waterskiing and other sports, it also has gorgeous Lake Mohave offering much of the same on a grander scale. Golfers will enjoy beautiful courses where reasonable green fees stretch their cash. For a taste of the Wild West, head to nearby 100-year-old Oatman, where you can catch a mock gunfight and guzzle beer in an old-time saloon. Hiking, anyone? Grapevine Canyon awaits you, famous for the Indian markings -- some 800 years old -- carved into its boulders. You'll find plenty of gaming houses, with water shuttles running between them 24/7. What Laughlin lacks in Vegas glamour, it makes up for in affordability, scenic beauty and aquatic fun.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.