Stretching 126 miles south towards Cuba, the stunning Keys are a perfect escape. Highlights along the way include Key Largo, Islamorada, Marathon, Big Pine Key and the irrepressible Key West. Come face to face with an amazing array of fish while snorkelling, diving or fishing in the warm turquoise waters. Creeks, coral and costumed shows are other lures along the way. Highway 1 is a spectacular ribbon tying together the islands and atolls of this paradise between the Gulf of Mexico and the Atlantic.

Six islands in the Florida Keys comprise the village of Islamorada, known for its prime sport fishing. Rent a boat or participate in a guided tour to fish, snorkel, or swim with marine life. Fresh seafood is the hallmark of the Islamorada dining scene. Visit a tropical-themed bar to soak in the full Florida Keys experience with a frozen umbrella drink. For a dose of culture, take in fine art and music while strolling through the Morada Way Art and Cultural District.

Key West has great nightlife—and a perfect cover story for someone who wants to enjoy it. A Hemingway fan simply must toss back a few at their hero’s favourite bar! You’re not reliving Spring Break, you’re immersing yourself in great American literature. Yeah. That’s the ticket.

Key Largo's spectacular Sandspur and Caloosa Beaches are a part of protected area Bahia Honda. This divine duo of sandy beaches, with their coconut palms and year-round warm waters, offer marvellous swimming, snorkelling and kayaking in their calm waters. Sandspur is especially popular with families.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Located along the Willamette River and its namesake lake, the city of Lake Oswego has a beautiful downtown area featuring riverfront parks, boutique shopping and speciality dining including a European-style farmers market open from May – October. Lake Oswego also offers visitors an active arts scene: Visitors can take a self-guided tour of the outdoor “Gallery Without Walls,” or attend the annual Festival of the Arts in June.