Stretching 126 miles south towards Cuba, the stunning Keys are a perfect escape. Highlights along the way include Key Largo, Islamorada, Marathon, Big Pine Key and the irrepressible Key West. Come face to face with an amazing array of fish while snorkelling, diving or fishing in the warm turquoise waters. Creeks, coral and costumed shows are other lures along the way. Highway 1 is a spectacular ribbon tying together the islands and atolls of this paradise between the Gulf of Mexico and the Atlantic.

Six islands in the Florida Keys comprise the village of Islamorada, known for its prime sport fishing. Rent a boat or participate in a guided tour to fish, snorkel, or swim with marine life. Fresh seafood is the hallmark of the Islamorada dining scene. Visit a tropical-themed bar to soak in the full Florida Keys experience with a frozen umbrella drink. For a dose of culture, take in fine art and music while strolling through the Morada Way Art and Cultural District.

Key West has great nightlife—and a perfect cover story for someone who wants to enjoy it. A Hemingway fan simply must toss back a few at their hero’s favourite bar! You’re not reliving Spring Break, you’re immersing yourself in great American literature. Yeah. That’s the ticket.

Key Largo's spectacular Sandspur and Caloosa Beaches are a part of protected area Bahia Honda. This divine duo of sandy beaches, with their coconut palms and year-round warm waters, offer marvellous swimming, snorkelling and kayaking in their calm waters. Sandspur is especially popular with families.

Cuba's top beach destination sits on a 13-mile-long peninsula with powder soft sands lapped by waters of the Kawama Channel. Resort hotels teem along the shore that U.S. celebrities and gangsters, including Capone, discovered in the 1920s. Clubs and bars provide mojitos and merriment, after long days baking on the beach, golfing, diving or deep sea fishing. Rent a scooter or hop aboard an open-air tourist train or bus to see more of this stunning spot. Caves, keys and virgin forest add to the area's allure.

It’s not just for spring-breakers. Cancun, with its golden beaches and perfect climate, is the premiere coastal destination in Mexico. And while there is certainly a 365-day party available for college students, resorts cater well to families and to those seeking solitude. This Yucatan paradise is also the gateway to the ruins of Tulum and Chichén Itzá.

Mexico's fastest-growing resort area offers miles of empty desert and deserted beaches. Laid-back nightlife and old-fashioned fun in the sun is the Cabos' lure. Only certain beaches are safe for swimming, however, including Lovers' Beach and the more tempestuous and aptly named Divorce Beach. Whale-watching, hang-gliding, snorkelling, antique-hunting, golf and fishing, Loreto's historic mission, and sport fishing and dining in capital La Paz are other attractions. SuburBaja buses travel the coast.

Positioned at the eastern tip of the Costa del Sol, Nerja boasts nearly 10 miles of powdery beaches featuring activities like water skiing, scuba diving and sailing. Although tourist-oriented, it hasn't been overtaken by high-rises, and its huge promenade delivers panoramic Mediterranean views.

The small city of Sitges parties big. The nightlife is thumping, the people are gorgeous and the annual Carnival festival is utterly epic. A countercultural touchstone, Sitges is lively and very LGBT friendly. Native food and beverage is sublime—you simply must sample the Malvasia wine, made from grapes descending from Ancient Greece. Don’t miss the Museu Romàntic "Can Llopis" or, if you’re in Sitges in October, the world-renowned Sitges Film Festival, a cinematic extravaganza of horror, sci-fi and fantasy.