Santo Domingo, the capital of the Dominican Republic and a UNESCO world heritage site, is the oldest continuously inhabited European settlement in the Americas and one of the most populous cities in the Caribbean. The city is a mix of old world charm and modern Latin flair. Its medieval palaces and fortresses mix with nightlife and shopping to rival any modern city in the world. You'll find pristine beaches and hidden gems like a salsa/merengue club set inside a huge underground cave.

Lively nightclubs pulsing with Caribbean beats drive the nightlife scene of Cabarate, a breathtaking beach town. Not even the stubbornly two-left-footed can keep their toes from tapping when the sun goes down on Cabarete, which brims with culture and energy. Beachfront bars cum discotheques are the perfect spot to shake what your Mami gave you.

Sosua is everything you want a beach town to be. Clear waters teem with coral, perfect for snorkeling and diving. Above sea level you’ll find multicolored sands lined with beach shacks. This small enclave of the Dominican Republic was once a haven for Jewish refugees. Historic sites and synagogues offer great perspective on Sosua’s postwar identity. On a lighter note, a community of ex-pats helps fuel a boisterous, international nightlife scene.

The ideal destination for families, honeymooners, divers and golfers alike, La Romana is home to the famous Casa de Campo resort, internationally renowned golf courses, a world-class marina and Altos de Chavón, a beautiful replica of a 16th-century artisan village. Nearby, the Bayahibe area offers picturesque beaches, chic accommodations, desirable attractions and splendid opportunities for ecotourism. Visitors can enjoy stunning Saona Island, Cotubanamá National Park and more.

Set in rugged, mountainous territory in the east, Cuba's fourth largest city is known as the City of Parks. Columbus called the area the most beautiful land eyes have ever seen and much of the surrounding area hasn't changed. Officially called San Isidro de Holguin, the city's elegant plazas, scatter of colonial buildings and few museums make for a pleasant daytrip. More wonders lie offshore. Swim with dolphins in Bahia de Naranjo Nature Park. Dive to sites off Playa Esmeralda and Guardalavaca.

An archipelago off the northwest coast of Panama, Bocas del Toro is an eco-tourism favorite with English-speaking and other tourists traveling to this Central American country. Seven islands (including Isla Colón, Isla Carenero and Isla Bastimentos) comprise the land area, with Bocas Town its regional capital and the “big city” for those looking to shop, dine well, and explore nightlife. Adventure lovers will find plenty to keep them occupied, as scuba diving, snorkeling, sailing, surfing and hiking are first-rate. And if you’re more of a tour-goer, never fear—Bocas del Toro offers a host of them, ranging from sailing to Nivida Bat Cave tours.

Just north of Cancun, this seaside resort community is a far cry from the spring-break crowd. Bordered on one side by the Mexican Caribbean and the other by a wetlands wildlife preserve, the vibe in Playa Mujeres is one of laid-back luxury in a natural, untouched landscape. Unlike many other such tranquil places, Playa Mujeres is not a pain to get to. It's an easy ride from Cancun airport.

Located on Mount Desert Island, home of the spectacular Acadia National Park, Bar Harbor is a historic tourist town, offering salty sea air, soft sandy beaches, granite cliffs and a slew of activities for the outdoor enthusiast. A 19th-century resort for the wealthy, the town has several mansions, old majestic hotels and other vestiges of its heyday. Stop by the Hulls Cove Visitor Center to stock up on information about Acadia National Park. Then pick from a wealth of activities: swimming, canoeing, kayaking, hiking, climbing mountains, bird or whale watching, cycling and horse riding. If kayaking is your sport, or you're itching to learn, Coastal Kayaking Tours offers trips for beginner to expert paddlers. Golfers can tee off at the scenic Kebo Golf Club, one of the oldest courses in the US. For a unique adventure, go on a boat excursion with Diver Ed, where you can watch Ed diving 50 feet below on the deck monitor and then learn about the starfish, sea urchins and other sea creatures he retrieves and then returns to their home.

Situated on the Dutch border, Limburg is the easternmost province in Flanders, and the foremost fruit-growing region in the country. The lively, friendly market town of Hasselt is the provincial capital. It boasts a car-free historic center, with building dating back as far as the 11th century. Genk is another recommended stop. The city of 63,000 people is home to a zoo, a planetarium, De Maten nature reserve and Bokrijk, an open-air museum of 19th century Flemish architecture.