Although not a crowded Caribbean tourist spot, Georgetown is a unique city that serves as a perfect jumping point for ecotours into the South American interior. Its Victorian and Dutch Colonial architecture is detailed with louvered window shutters and brick and stone work. Built below the high tide level, the city is protected by a large seawall and drained by a grid of canals. Sundry goods can be found at the distinctive Stabroek Market, while the landmark Light House offers panoramic views.

When you can trek through the rainforests in the morning and take in a tear-jerking opera at night, you know you're in a special place. Manaus offers a rich variety of nature, culture, art and dining. Explore the lush vegetation of Amazonian jungle on a guided backpacking or river tour, or sample the colorful bounty of the Mercado Adolpho Lisboa. The stately Amazonas Opera House was built with the finest materials, and inside you'll be blown away by powerful performances.