Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Tucked away in the heart of the northern Rocky Mountains, Missoula is the perfect spot for a weekend of history, culture and outdoor fun. Home to the University of Montana, one of the country's most architecturally distinguished academic institutions, the city offers a number of intellectually stimulating attractions. Spend a few hours browsing through the exhibits at the Art Museum of Missoula or take a trip back in time at the Historical Museum at Fort Missoula. The city's proximity to three major rivers and acres of lush forest means that visitors can also enjoy a host of activities, from fly fishing and kayaking to hiking and cycling. Missoula's historic downtown area has classic early 20th-century buildings and boasts unique shops, galleries, fine dining and a lively nightlife. If you've got children with you, don't miss Dragon Hollow, a magical playground that features an extraordinary hand-carved carousel.

Located along the Willamette River and its namesake lake, the city of Lake Oswego has a beautiful downtown area featuring riverfront parks, boutique shopping and speciality dining including a European-style farmers market open from May – October. Lake Oswego also offers visitors an active arts scene: Visitors can take a self-guided tour of the outdoor “Gallery Without Walls,” or attend the annual Festival of the Arts in June.