If you’re into eating locally and supporting sustainable agriculture, go to Ashville—and eat, eat, eat. This town of less than 100,000 people has 17 farmers’ markets, and the local restaurant scene is all about taking advantage of the seasonal produce sold there. And don’t miss the area’s microbreweries.

Located at the entrance to the Great Smoky Mountains National Park, Cherokee is the headquarters for the Eastern Band of Cherokee Indians. Signs around town are in English and Cherokee, and the city itself is anchored by the Harrah's Cherokee Casino. The tourist-oriented area is rich in outdoor activities for the entire family. The tribe runs a botanical garden, cultural museum, Indian village recreation, historical dramas, and an arts and crafts center.

Don't let Bloomington's modest size fool you; this Midwestern city offers as much sophistication as it does all-American charm. At Indiana University you will find cutting edge theatrical performances, museums and sports. Check out 4th Street's Restaurant Row for fine international dining. Head downtown for galleries, theaters and fun spots for the kids. Year round festivals will keep you entertained in any season.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Wine lovers: whether you’re a die-hard oenophile or just a general grape enthusiast, you’ll be thrilled by the vineyards and cellars of Santa Cruz. This Chilean city makes a great base for exploring the Colchagua Valley, a wine region that’s loved for its full-bodied reds. Before you embark upon a day of tastings, be sure to explore Santa Cruz’s charming colonial architecture and cultural museums.