Houston hums with an energy and independent spirit all its own. A leading cultural and culinary destination in the South, the city is home to over 11,000 restaurants featuring cuisine from more than 70 countries. The thriving arts scene includes resident opera, ballet, symphony and theatre companies. The Museum District houses 19 museums, all within walking distance. Be sure to visit Space Centre Houston, where you can visit NASA’s Historic Mission Control at the Johnson Space Centre.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Middletown, Rhode Island, is home to miles of wide sandy beaches, thousands of acres of unspoiled nature preserves, historic attractions, outdoor recreation and many restaurants. Bordering the popular resort city of Newport, this diverse coastal community is where you’ll find the Norman Bird Sanctuary, which encompasses more than 325 acres of diverse habitats and seven miles of marked trails, as well as the Sachuest Point National Wildlife Refuge, which offers a 2.5-mile trail with panoramic ocean views.