New Buffalo is a Lake Michigan beach getaway convenient to Indiana and Chicago. The large, broad public beach is the main attraction, but you can also explore downtown New Buffalo's shopping and dining options. Or, if you feel like taking a chance, the Four Winds Casino Resort has 130,000 square feet of gaming space. Owned by the Pokagon Band of Potawatomi Indians, its design evokes their heritage.

The 150-year-old University of Notre Dame is South Bend's biggest tourist draw, and for good reason. Though it's not easy to land seats at the 80,000-plus-capacity Notre Dame Stadium for a "Fighting Irish" football game, you'll find plenty of attractions on the beautiful, expansive campus. Highlights include numerous works of art, the Basilica of the Sacred Heart and the Grotto of Our Lady of Lourdes, a replica of the famous shrine. Football fans will also want to visit the College Football Hall of Fame, which features interesting perspectives on the game and inductee videos. Whether or not you remember the Studebaker automobile, which saw its demise in the early sixties, you're sure to enjoy the Studebaker National Museum, featuring more than 75 vehicles drawn from the history of the company, beginning with horse-drawn carriages. South Bend has several fine museums, including the South Bend Regional Museum of Art and the Northern Indiana Centre for History, a complex of four museums. Don't leave without trying truffles or fudge from the South Bend Chocolate Company.

The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."