Nestled between the shrub-covered slopes of the Santa Ynez Mountains and the clear blue shores of the Pacific Ocean, Santa Barbara is California at its best. Mission Santa Barbara is an example of 18th-century religious architecture, boasting beautiful grounds and a wonderfully detailed interior. Work up an appetite with a walk through Shoreline Park, then dine above the water on Stearns Wharf. Fig trees, parks, waterfalls, and botanical gardens round out Santa Barbara’s natural beauty.

The acclaimed Rancho La Puerta is Mexico’s top destination spa. Set within spectacular grounds, just an hour from San Diego, therapeutic treatments make full use of all kinds of medicine and produce from the Rancho’s organic garden. This idyllic sanctuary is a luxurious full service spa resort.

The industrial city of Monterrey is reigned over by the mighty Cerro de Silla, a mountain that galvanizes adventurers with its steep hiking trails. Within the city, an 18th-century neighbourhood impresses with its architecture and harbours what’s hailed as Mexico’s most beautiful bookshop.

During the Civil War, Knoxville's Mabry-Hazen House served as headquarters for both the Confederate and Union armies. Today you can visit the house and other historic homes in this eastern Tennessee city. Among Knoxville's other attractions are museums, a zoo and the park that housed the 1982 World's Fair. University of Tennessee sports draw lots of fans, as does the Women's Basketball Hall of Fame. To see Knoxville from the water, take a leisurely riverboat ride down the Tennessee River.

Home to the University of Florida, the largest and oldest university in the state, as well as the Santa Fe Community College, Gainesville is a hub of education and culture. Perhaps due to its strong student population, the city is also at the heart of independent music in Florida, having produced numerous musical acts from a variety of genres. The natural surroundings, including parks, lakes and the adjacent Paynes Prairie State Reserve provide a green getaway from the bustle of city life.

Once an important center for sugar production, Puerto Rico's fourth largest city's current fortunes come from its factories. Intriguing nicknames for the city of nearly 200,000 include The Land of Giants and Arm Hackers Town. Situated on the island's north shore, this Atlantic city is considered part of the metropolitan San Juan area. Popular attractions include Carolina Beach, Casa Escute art gallery, Caribbean Raceway Park and Isla Verde Mall. To make the most of your visit, consider renting a car.

Once infamous for dangerous gangs and drug activity, Medellin has been transformed. It’s now a vibrant destination for travelers seeking a culturally rich vacation. Medellin rises proudly from the belly of the Aburrá Valley, and its natural beauty makes a perfect setting for hiking, zip lining and horseback riding. Travel through lush jungle to Piedra de Penol, then climb the 740 steps to the top—a journey within a journey that rewards you with unforgettable views.