There‘s a really wide range of exhibits here - if you viewed everything in detail this would take you a day at least. I spent over five hours here and I skipped a number of exhibits and skimmed others.
In the main building I recommend the Zuse computers exhibit, telecommunications, shipping, and sugar.
There is also a harder-to-find set of exhibits away from the main building on Ladestraße. This had exhibits about computing and networks, road transport, and temporary exhibits on German public transport (German-only). Loved this building.
Some minor issues: a lot of the interactive parts of exhibitions were shut or disabled (I presume covid), some exhibitions are German-language-only, and some exhibitions were closed entirely.